Pregnancy, Live Birth Resulting From Cryopreserved Embryos
Pregnancy, Live Birth Resulting From Cryopreserved Embryos
In vitro maturation (IVM) of immature oocytes retrieved from surgically resected ovaries has been proposed as a method of fertility preservation in ovarian cancer patients undergoing definitive surgery. While there had been several reports of successful derivation of mature oocytes and or embryos, there have been no reports as yet of successful pregnancies. In this case report, we present a pregnancy and live birth from a young patient, with stage IIIC ovarian cancer, who had undergone fertility sparing surgery. The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.
In vitro maturation (IVM) of oocytes harvested from ovaries in cases of cancer forms an integral part of fertility preservation. Oocytes harvested from ovaries ex vivo have been reported, with successful vitrification of matured oocytes. Although an attempt at transferring embryos from obtained frozen–thawed in vitro matured oocytes has been reported (Fadini et al., 2012), there had been no pregnancies reported to date. Here we present a case report of a successful pregnancy and live birth after the transfer of frozen–thawed embryos obtained from oocytes which had been recovered from a cancerous ovary after oophorectomy, matured in vitro and fertilized by ICSI. This approach was used in the context of ovarian cancer in a young woman with recurrent ovarian tumours.
Abstract and Introduction
Abstract
In vitro maturation (IVM) of immature oocytes retrieved from surgically resected ovaries has been proposed as a method of fertility preservation in ovarian cancer patients undergoing definitive surgery. While there had been several reports of successful derivation of mature oocytes and or embryos, there have been no reports as yet of successful pregnancies. In this case report, we present a pregnancy and live birth from a young patient, with stage IIIC ovarian cancer, who had undergone fertility sparing surgery. The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.
Introduction
In vitro maturation (IVM) of oocytes harvested from ovaries in cases of cancer forms an integral part of fertility preservation. Oocytes harvested from ovaries ex vivo have been reported, with successful vitrification of matured oocytes. Although an attempt at transferring embryos from obtained frozen–thawed in vitro matured oocytes has been reported (Fadini et al., 2012), there had been no pregnancies reported to date. Here we present a case report of a successful pregnancy and live birth after the transfer of frozen–thawed embryos obtained from oocytes which had been recovered from a cancerous ovary after oophorectomy, matured in vitro and fertilized by ICSI. This approach was used in the context of ovarian cancer in a young woman with recurrent ovarian tumours.
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